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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 19 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Glutamine (Free-Form)
1 g (1,000 mg)
**
Top Medical Research Studies
9.5
Glutamine reduces IBS-D symptoms
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.
Highly relevant treatment evaluation
We examined the potential of l-glutamine as a treatment for postinfectious irritable bowel syndrome, specifically focusing on patients who experience diarrhea as a primary symptom. This study was a well-structured, randomized, double-blind, placebo-controlled trial that lasted for eight weeks.
Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).
Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.
The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.
Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).
Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.
The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.
Read More
9
Glutamine enhances IBS dietary treatment
Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management.
High relevance for IBS research
We conducted a clinical trial to explore how adding l-glutamine to a low FODMAP diet affects individuals with irritable bowel syndrome (IBS). In this study, 50 eligible adults were randomly divided into two groups: one group received the low FODMAP diet along with 15 grams of glutamine daily, while the other received a placebo for six weeks.
Our primary focus was to see whether this combination would significantly reduce IBS symptom severity. We also looked at changes in other IBS-related symptoms, stool habits, and quality of life. Remarkably, participants who took glutamine reported a significant decrease in overall IBS severity scores, satisfaction with bowel habits, and how much IBS interfered with their daily life.
Out of the participants who received glutamine, an impressive 88% experienced more than a 45% improvement in their IBS symptoms, compared to only 60% in the placebo group. Importantly, no serious side effects were reported.
These findings suggest that adding l-glutamine to a low FODMAP diet can enhance the management of IBS symptoms, affirming the effectiveness of dietary strategies in treating this challenging condition.
Our primary focus was to see whether this combination would significantly reduce IBS symptom severity. We also looked at changes in other IBS-related symptoms, stool habits, and quality of life. Remarkably, participants who took glutamine reported a significant decrease in overall IBS severity scores, satisfaction with bowel habits, and how much IBS interfered with their daily life.
Out of the participants who received glutamine, an impressive 88% experienced more than a 45% improvement in their IBS symptoms, compared to only 60% in the placebo group. Importantly, no serious side effects were reported.
These findings suggest that adding l-glutamine to a low FODMAP diet can enhance the management of IBS symptoms, affirming the effectiveness of dietary strategies in treating this challenging condition.
Read More
8
Glutamine strengthens intestinal barrier function
Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction.
Indirect implications for IBS treatment
The study we examined explored the effects of l-glutamine on intestinal barrier function, specifically in the context of irritable bowel syndrome (IBS). We observed that impaired barrier function is a common issue for those with IBS and inflammatory bowel disease (IBD), both of which can lead to discomfort and health complications.
In our research setup, we used Caco-2 cells, a model for human intestinal epithelial cells, which allowed us to investigate the impact of interleukin-13 (IL-13) on barrier function. We found that when IL-13 was introduced, it significantly lowered the integrity of the barrier. This was evidenced by decreased transepithelial electrical resistance (TEER) and increased permeability, meaning that the cells were letting more substances pass through than they should.
However, when we added l-glutamine, we noticed a reversal of these negative effects. L-glutamine helped to restore some of the lost barrier function by increasing the levels of claudin-1, a crucial protein that supports tight junctions between cells, while inhibiting claudin-2, which can contribute to increased permeability. Furthermore, l-glutamine's beneficial effects were tied to its ability to interfere with a specific signaling pathway involving phosphatidylinositol-3-kinase (PI3K).
While our results indicate that l-glutamine can play a role in reinforcing the intestinal barrier, the study's implications for IBS are indirect and further research is needed to fully confirm the isolated benefits of l-glutamine for patients suffering from IBS symptoms.
In our research setup, we used Caco-2 cells, a model for human intestinal epithelial cells, which allowed us to investigate the impact of interleukin-13 (IL-13) on barrier function. We found that when IL-13 was introduced, it significantly lowered the integrity of the barrier. This was evidenced by decreased transepithelial electrical resistance (TEER) and increased permeability, meaning that the cells were letting more substances pass through than they should.
However, when we added l-glutamine, we noticed a reversal of these negative effects. L-glutamine helped to restore some of the lost barrier function by increasing the levels of claudin-1, a crucial protein that supports tight junctions between cells, while inhibiting claudin-2, which can contribute to increased permeability. Furthermore, l-glutamine's beneficial effects were tied to its ability to interfere with a specific signaling pathway involving phosphatidylinositol-3-kinase (PI3K).
While our results indicate that l-glutamine can play a role in reinforcing the intestinal barrier, the study's implications for IBS are indirect and further research is needed to fully confirm the isolated benefits of l-glutamine for patients suffering from IBS symptoms.
Read More
Most Useful Reviews
9.5
Pain alleviation
I have Leaky Gut Syndrome and find this product excellent. It has significantly relieved my pain, which I believe is healing my condition.
Read More
9
Heaviness relief
I bought this to address my leaky gut syndrome, and it worked! After starting on a single capsule daily, the uncomfortable feelings after eating have diminished considerably. I feel much healthier after a year.
Read More
9.5
Diarrhoea control
I recommend this to anyone with irritable bowel syndrome. My mother, 71, has seen remarkable improvements with her stool regularity and reduced discomfort after starting this supplement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
9.5
Glutamine reduces IBS-D symptoms
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.
Highly relevant treatment evaluation
We examined the potential of l-glutamine as a treatment for postinfectious irritable bowel syndrome, specifically focusing on patients who experience diarrhea as a primary symptom. This study was a well-structured, randomized, double-blind, placebo-controlled trial that lasted for eight weeks.
Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).
Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.
The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.
Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).
Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.
The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.
Read More
9
Glutamine enhances IBS dietary treatment
Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management.
High relevance for IBS research
We conducted a clinical trial to explore how adding l-glutamine to a low FODMAP diet affects individuals with irritable bowel syndrome (IBS). In this study, 50 eligible adults were randomly divided into two groups: one group received the low FODMAP diet along with 15 grams of glutamine daily, while the other received a placebo for six weeks.
Our primary focus was to see whether this combination would significantly reduce IBS symptom severity. We also looked at changes in other IBS-related symptoms, stool habits, and quality of life. Remarkably, participants who took glutamine reported a significant decrease in overall IBS severity scores, satisfaction with bowel habits, and how much IBS interfered with their daily life.
Out of the participants who received glutamine, an impressive 88% experienced more than a 45% improvement in their IBS symptoms, compared to only 60% in the placebo group. Importantly, no serious side effects were reported.
These findings suggest that adding l-glutamine to a low FODMAP diet can enhance the management of IBS symptoms, affirming the effectiveness of dietary strategies in treating this challenging condition.
Our primary focus was to see whether this combination would significantly reduce IBS symptom severity. We also looked at changes in other IBS-related symptoms, stool habits, and quality of life. Remarkably, participants who took glutamine reported a significant decrease in overall IBS severity scores, satisfaction with bowel habits, and how much IBS interfered with their daily life.
Out of the participants who received glutamine, an impressive 88% experienced more than a 45% improvement in their IBS symptoms, compared to only 60% in the placebo group. Importantly, no serious side effects were reported.
These findings suggest that adding l-glutamine to a low FODMAP diet can enhance the management of IBS symptoms, affirming the effectiveness of dietary strategies in treating this challenging condition.
Read More
8
Effectiveness of CGEC on IBS
To assess the effective and safety of compound glutamine entersoluble capsules in irritable bowel syndrome: A protocol for systematic review and meta-analysis.
L-glutamine's separate impact unclear
We investigated the potential benefits of using Compound Glutamine Entersoluble Capsules (CGEC) for treating individuals with irritable bowel syndrome (IBS). The research focuses on how well these capsules, which combine key ingredients like L-glutamine, ginseng, licorice, Atractylodes macrocephala, and Poria cocos, can alleviate symptoms and improve quality of life for those suffering from IBS.
The study design involved searching through various databases to find relevant studies on CGEC's effects on IBS, particularly looking for clinical trials published up to January 2021. A systematic review and meta-analysis were conducted, which included evaluating the risk of bias in the eligible studies and checking for data synthesis using software tools.
However, it's important to note that the research did not indicate a significant isolated effect of L-glutamine on IBS symptoms. This means that while CGEC had promise, the specific impact of L-glutamine alone in improving IBS symptoms remains unclear.
In conclusion, we assessed CGEC's effectiveness and safety in treating IBS but found no conclusive evidence endorsing the isolated benefits of L-glutamine for this condition.
The study design involved searching through various databases to find relevant studies on CGEC's effects on IBS, particularly looking for clinical trials published up to January 2021. A systematic review and meta-analysis were conducted, which included evaluating the risk of bias in the eligible studies and checking for data synthesis using software tools.
However, it's important to note that the research did not indicate a significant isolated effect of L-glutamine on IBS symptoms. This means that while CGEC had promise, the specific impact of L-glutamine alone in improving IBS symptoms remains unclear.
In conclusion, we assessed CGEC's effectiveness and safety in treating IBS but found no conclusive evidence endorsing the isolated benefits of L-glutamine for this condition.
Read More
8
Glutamine strengthens intestinal barrier function
Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction.
Indirect implications for IBS treatment
The study we examined explored the effects of l-glutamine on intestinal barrier function, specifically in the context of irritable bowel syndrome (IBS). We observed that impaired barrier function is a common issue for those with IBS and inflammatory bowel disease (IBD), both of which can lead to discomfort and health complications.
In our research setup, we used Caco-2 cells, a model for human intestinal epithelial cells, which allowed us to investigate the impact of interleukin-13 (IL-13) on barrier function. We found that when IL-13 was introduced, it significantly lowered the integrity of the barrier. This was evidenced by decreased transepithelial electrical resistance (TEER) and increased permeability, meaning that the cells were letting more substances pass through than they should.
However, when we added l-glutamine, we noticed a reversal of these negative effects. L-glutamine helped to restore some of the lost barrier function by increasing the levels of claudin-1, a crucial protein that supports tight junctions between cells, while inhibiting claudin-2, which can contribute to increased permeability. Furthermore, l-glutamine's beneficial effects were tied to its ability to interfere with a specific signaling pathway involving phosphatidylinositol-3-kinase (PI3K).
While our results indicate that l-glutamine can play a role in reinforcing the intestinal barrier, the study's implications for IBS are indirect and further research is needed to fully confirm the isolated benefits of l-glutamine for patients suffering from IBS symptoms.
In our research setup, we used Caco-2 cells, a model for human intestinal epithelial cells, which allowed us to investigate the impact of interleukin-13 (IL-13) on barrier function. We found that when IL-13 was introduced, it significantly lowered the integrity of the barrier. This was evidenced by decreased transepithelial electrical resistance (TEER) and increased permeability, meaning that the cells were letting more substances pass through than they should.
However, when we added l-glutamine, we noticed a reversal of these negative effects. L-glutamine helped to restore some of the lost barrier function by increasing the levels of claudin-1, a crucial protein that supports tight junctions between cells, while inhibiting claudin-2, which can contribute to increased permeability. Furthermore, l-glutamine's beneficial effects were tied to its ability to interfere with a specific signaling pathway involving phosphatidylinositol-3-kinase (PI3K).
While our results indicate that l-glutamine can play a role in reinforcing the intestinal barrier, the study's implications for IBS are indirect and further research is needed to fully confirm the isolated benefits of l-glutamine for patients suffering from IBS symptoms.
Read More
8
Glutamine affects tight junctions in IBS-D
Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome.
Focused on IBS-D tight junctions
We aimed to explore how l-glutamine treatment impacts patients with diarrhea-predominant irritable bowel syndrome (IBS-D), particularly focusing on the regulation of tight junction proteins. Our study involved twelve patients diagnosed with IBS-D, who underwent an 18-hour treatment with varying concentrations of l-glutamine.
After treatment, we measured claudin-1 and occludin, the proteins crucial for maintaining the integrity of gut barriers. We found that l-glutamine significantly increased claudin-1 levels at higher concentrations, suggesting a beneficial effect. Specifically, a concentration of 10 mmol/L l-glutamine led to a notable rise in claudin-1 compared to the lower concentration of 0.6 mmol/L.
Interestingly, the expression of another tight junction protein, occludin, did not show any significant change with l-glutamine treatment. Moreover, the positive effects of l-glutamine were observed to be more pronounced in individuals with lower baseline levels of tight junction proteins, indicating that the treatment might be particularly beneficial for those with greater protein deficiencies.
Overall, while l-glutamine appears to enhance claudin-1 expression in the colonic mucosa for IBS-D patients, further investigation will be necessary to understand its full impact on overall IBS symptoms and gut health.
After treatment, we measured claudin-1 and occludin, the proteins crucial for maintaining the integrity of gut barriers. We found that l-glutamine significantly increased claudin-1 levels at higher concentrations, suggesting a beneficial effect. Specifically, a concentration of 10 mmol/L l-glutamine led to a notable rise in claudin-1 compared to the lower concentration of 0.6 mmol/L.
Interestingly, the expression of another tight junction protein, occludin, did not show any significant change with l-glutamine treatment. Moreover, the positive effects of l-glutamine were observed to be more pronounced in individuals with lower baseline levels of tight junction proteins, indicating that the treatment might be particularly beneficial for those with greater protein deficiencies.
Overall, while l-glutamine appears to enhance claudin-1 expression in the colonic mucosa for IBS-D patients, further investigation will be necessary to understand its full impact on overall IBS symptoms and gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.6
9.5
Gut function improvement
I was recommended this product by my nutritionist to help repair my gut lining due to candida. I've seen a notable improvement in bowel function, and my symptoms return if I stop taking it. I won't be without this, given its price and quality.
9.5
Symptoms nearly gone
I've struggled with candida overgrowth for years. After taking this product, my symptoms such as headaches and itching have almost completely disappeared, allowing me to eat certain foods again, as long as I refrain from overindulging.
9.5
Supports gut healing
I appreciate glutamine for its ability to restore the intestinal mucosa and manage "leaky gut syndrome". It also enhances immune function and supports liver cells, making it a valuable addition to my routine.
9.5
Pain alleviation
I have Leaky Gut Syndrome and find this product excellent. It has significantly relieved my pain, which I believe is healing my condition.
9.5
Diarrhoea control
I recommend this to anyone with irritable bowel syndrome. My mother, 71, has seen remarkable improvements with her stool regularity and reduced discomfort after starting this supplement.
